G. Zhu

Heterogeneous hybrid immunity against Omicron variant JN.1 at 11 months following breakthrough infection

This study evaluates hybrid immunity against the Omicron variant JN.1 11 months after breakthrough infection, showing heterogeneous responses and increased neutralization following reinfection.

Cbfβ regulates Wnt/β-catenin, Hippo/Yap, and TGFβ signaling pathways in articular cartilage homeostasis and protects from ACLT surgery-induced osteoarthritis

This study shows that Cbfβ deficiency leads to OA by altering Wnt/β-catenin, Hippo/Yap, and TGFβ signaling, and that local Cbfβ overexpression protects against OA in mice.

Transdifferentiation of fibroblasts into muscle cells to constitute cultured meat with tunable intramuscular fat deposition

This study transdifferentiates chicken fibroblasts into muscle cells with tunable fat deposition to create cultured meat mimics with controllable intramuscular fat content.

Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify on/off-target rates

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

SARS-CoV-2 variant B.1.1.7 caused HLA-A2+ CD8+ T cell epitope mutations for impaired cellular immune response

This study identifies mutations in SARS-CoV-2 variant B.1.1.7 that reduce HLA-A2 restricted CD8+ T cell epitope binding and impair cellular immune responses.

Brain Injury Localization in Electromagnetic Imaging using Symmetric Crossing Lines Method

This paper introduces a novel method for localizing brain injuries using symmetric antenna signal intersections and demonstrates an accuracy of 0.85 Dice similarity coefficient.

Mosaic Evolution of Beta Barrel Porin Encoding Genes in Escherichia coli

The paper identifies mosaic evolution in multiple beta-barrel porin genes in E. coli, showing local recombination and sequence variation that may help bacteria evade environmental threats.

Identification of age and ethnicity specific gene expression biomarkers for immune aging

This study identifies age and ethnicity-specific gene expression biomarkers for immune aging using transcriptomic data from peripheral blood mononuclear cells.

CD8+ T cell epitope variations suggest a potential antigen presentation deficiency for spike protein of SARS-CoV-2

The paper identifies HLA-A2 restricted T cell epitopes in SARS-CoV-2 spike protein and finds that variations in these epitopes may reduce T cell activation and contribute to immune escape.

Pan-genome analyses of peach and its wild relatives provide insights into the genetics of disease resistance and species adaptation

The paper performs pan-genome analysis of peach and its wild relatives to identify genetic variations related to disease resistance and high-altitude adaptation.

Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

Origin and cross-species transmission of bat coronaviruses in China

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

Assessing the ecological niche and invasion potential of the Asian giant hornet

This study assesses the ecological niche and invasion potential of the Asian giant hornet using bioclimatic variables and dispersal simulations, identifying suitable habitats globally and highlighting risks in North America.

Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer

The paper uses single-cell RNA sequencing to analyze immune cell composition in brain metastases of NSCLC patients, finding reduced T cell activity and expanded M2-polarized tumor-associated macrophages.

Engineering of membrane complex sphingolipids improves osmotic tolerance of Saccharomyces cerevisiae

This paper shows overexpression of ELO2 in yeast increases complex sphingolipids, improving osmotic tolerance and cell survival under high salt conditions.

Admistration of Exogenous Melatonin Improves the Diurnal Rhythms of Gut Microbiota in High Fat Diet-Fed Mice

This study shows that exogenous melatonin administration restores diurnal rhythms in gut microbiota and host metabolism in high fat diet-fed mice.

The Evolution and Sequence Diversity of FhuA in Salmonella and Escherichia

This paper investigates the sequence diversity and evolutionary patterns of the fhuA gene in Salmonella and Escherichia, revealing unique clustering and mutation patterns that suggest gene recombination and selection pressure.

The Function of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo

This study shows SEC23A and SEC23B are functionally interchangeable in vivo, suggesting phenotypic differences arise from gene expression rather than protein function.