T. Hagai

A comparative analysis of the antiviral response in two bat species reveals conserved and divergent innate immune pathways

This study compares antiviral responses in two bat species, finding conserved gene upregulation and divergent transcriptional patterns linked to viral tolerance and resistance.

Lifelong tissue memory relies on spatially organised dedicated progenitors located distally from the injury

The paper shows that wound repair leads to the formation of spatially organized memory progenitors that enhance future wound healing but also increase tumorigenesis risk.

Rapidly evolving viral motifs target biophysically constrained binding pockets of host proteins

This study identifies how rapidly evolving viral motifs target biophysically constrained host protein binding pockets, revealing differences in conservation and interaction patterns between viral and host domains.

Promoter architecture links gene duplication with transcriptional divergence

The paper links promoter architecture with gene duplication rates and transcriptional divergence, showing CGI-less genes duplicate more frequently and show greater expression divergence.

Poised cell circuits in human skin are activated in disease

The paper creates a single-cell atlas of human skin, showing how cell circuits change in inflammatory diseases like atopic dermatitis and psoriasis.

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

Gene expression variability across cells and species shapes innate immunity

The paper examines how gene expression variability across cells and species influences innate immune responses, finding that rapidly diverging genes show high variability while regulatory genes are conserved.