CD4+ T cell senescence is associated with reduced reactogenicity in severe/critical COVID-19
J. Zhang, C. Chang, Z. Liang, T. Hu, Z. Yin, Y. Liang, T. Zhang, Y. Ding, X. Li, X. Gai, X. Yang, X. Li, X. Dong, J. Ren, Y. Rao, , L. Xue
The paper finds that higher levels of CD4+ T cell senescence in severe/critical COVID-19 patients correlate with reduced antibody responses and worse survival, especially in breakthrough infections.
bioRxiv · Aug 4, 2023 · PreprintImmunology