Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition
Yue Zeng, Ting Zhang, Elisa Eleanor Cornish, Sora Lee, Michelle Yam, Mark Eminhizer, Jingwen Zeng, Jialing Zhang, Shaoxue Zeng, Xian Wei, Jinliang Yang, Meidong Zhu, Andrew Chang, Meixia Zhang, Jianhai Du, , Mark C. Gillies
This study identifies proline metabolism, specifically proline hydroxylation via P4HA1, as a driver of subretinal fibrosis in nAMD and shows that P4HA1 inhibition reduces fibrosis in mouse models.
bioRxiv · Apr 13, 2025 · PreprintNeuroscience