Author

Meidong Zhu

The University of SydneyORCID 0000-0002-1192-0537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jianhai DuiD· 3 shared Michelle YamiD· 3 shared Sora LeeiD· 3 shared Andrew Chang· 2 shared Fanfan ZhouiD· 2 shared Jialing ZhangiD· 2 shared Jingwen ZengiD· 2 shared Ling ZhuiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersNeuroscience

Jianhai DuORCID

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3 papers

Recent·Most cited

Role of Alanine Transaminase in Retinal Metabolic Homeostasis: Potential therapeutic target in retinal diseases

Qin Chen, Ting Zhang, Jingwen Zeng, Michelle Yam, Sora Lee, Fanfan Zhou, Meidong Zhu, Ming Zhang, Fang Lu, Jianhai Du, Mark Gillies, Ling Zhu

This study investigates the role of alanine transaminase (ALT) in human neural retina metabolism, showing its involvement in carbon/nitrogen flux and redox balance, with potential therapeutic implications for retinal diseases.

bioRxiv · Apr 22, 2026 · PreprintNeuroscience

Sacrificing Adaptability for Functionality: The Ivory Tower of Macular Muller Cells

Ting Zhang, Kaiyu Jin, Shaoxue Zeng, Penghui Yang, Meidong Zhu, Jialing Zhang, Yingying Chen, Sora Lee, Michelle Yam, Yue Zeng, Xiaoyan Lu, Lipin Loo, G. Gregory Neely, Andrew Chang, Fanfan Zhou, , Mark C. Gillies

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

Redox Biology · May 24, 2025Peer-reviewedNeuroscience

Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition

Yue Zeng, Ting Zhang, Elisa Eleanor Cornish, Sora Lee, Michelle Yam, Mark Eminhizer, Jingwen Zeng, Jialing Zhang, Shaoxue Zeng, Xian Wei, Jinliang Yang, Meidong Zhu, Andrew Chang, Meixia Zhang, Jianhai Du, , Mark C. Gillies

This study identifies proline metabolism, specifically proline hydroxylation via P4HA1, as a driver of subretinal fibrosis in nAMD and shows that P4HA1 inhibition reduces fibrosis in mouse models.

bioRxiv · Apr 13, 2025 · PreprintNeuroscience