Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission
Anupama Tiwari, Jongyun Myeong, Arsalan Hashemiaghdam, Hao Zhang, Xianfeng Niu, Marissa A. Laramie, Marion I. Stunault, Jasmin Sponagel, Gary J. Patti, Leah P. Shriver, Vitaly A. Klyachko, Ghazaleh Ashrafi
This study shows that pyruvate supports neuronal viability without glucose and that mitochondrial pyruvate uptake regulates synaptic transmission in hippocampal terminals.
Science Advances · Nov 15, 2024Peer-reviewedNeuroscience