Ghazaleh Ashrafi

The paper shows the ketogenic diet reduces excitatory synaptic gain by shrinking synaptic vesicle pools through transcriptional and epigenetic changes in the hippocampus.

This study shows that pyruvate supports neuronal viability without glucose and that mitochondrial pyruvate uptake regulates synaptic transmission in hippocampal terminals.

The paper shows that mitochondria, not glycolysis, regulate vesicle release probability and location in hippocampal synapses, and that mitochondrial inhibition increases ultrafast endocytosis.

This study shows that Sirt3 is induced during glucose deprivation and supports synaptic transmission by enhancing mitochondrial function and synaptic vesicle recycling.

This paper develops a semi-automated pipeline using machine learning to improve ATP measurement accuracy in nerve terminals from bioluminescence images.

The paper shows that Pink1 mRNA is transported with mitochondria and tethered by SYNJ2BP and SYNJ2 to support local mitophagy in neurons.

The paper shows that axonal mitochondria use MICU3 to adjust Ca2+ uptake sensitivity, enabling metabolic flexibility in neurotransmission under varying fuel conditions.