Calcium Homeostasis Modulator 2 Constitutes an ATP-regulation Pore in Mitochondria
Qian-Jin Guo, Tingting Hou, Wen-Jun Xie, Jing-Ruo Zhang, Xin-Lei Ma, Yingna Guo, Xiao-Ting Wang, Li-Peng Wang, Ming-Ao Lu, Zhaofa Wu, Hong-Guang Wang, Yi-Hang Chen, Yu-Long Li, Shi-Qiang Wang
This study identifies CALHM2 as an ATP-regulated mitochondrial channel, showing it affects ATP levels and mTOR pathway activity, with implications for aging and disease.
bioRxiv · Sep 30, 2024 · PreprintCell Biology