Neutrophil-targeted delivery of circSCMH1 unlocks an acute anti-thromboinflammatory function to restore microvascular perfusion in stroke
Lian Xu, Xinxin Huang, Zhongqiu Zhou, Yanpeng Jia, Shuo Leng, Ying Bai, Bing Han, Honghong Yao
This study identifies circSCMH1 as a marker for futile recanalization in stroke and shows that targeted delivery of circSCMH1 reduces inflammation and improves microvascular perfusion.
bioRxiv · Mar 13, 2026 · PreprintNeuroscience