IgG Propels Atherosclerosis by Noncanonically Activating Macrophages
Tarik Zahr, Kai Zhang, Shengkang Huang, Chenyi Xue, Lexiang Yu, Zhewei Yu, Bing Li, Dongyang Liang, Qian Wang, Mariya Shadrina, Qianfen Wan, Xueming Li, Fuping You, Amy Kontorovich, Muredach P. Reilly, , Li Qiang
This study identifies IgG's pro-atherogenic role through noncanonical activation of macrophages, independent of its classical function, by acting as a TLR4 ligand and promoting inflammation.
bioRxiv · Mar 17, 2026 · PreprintImmunology