Author

Y. Brueggemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. Todt· 5 shared E. Steinmann· 5 shared S. Pfaender· 3 shared R. J. P. Brown· 2 shared T. L. Meister· 2 shared A. Goemer· 1 shared A. Kratzel· 1 shared A. Krawczyk· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersMicrobiology

D. Todt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes

N. Frericks, R. J. P. Brown, B. M. Reinecke, M. Herrmann, Y. Brueggemann, D. Todt, C. Miskey, F. Vondran, E. Steinmann, T. Pietschmann, J. A. Sheldon

This study identifies cell culture adaptive mutations in HCV that enhance replicative fitness in cell lines but reduce virion production in primary human hepatocytes by boosting antiviral responses.

bioRxiv · Nov 22, 2023 · PreprintMolecular Biology

Targeting cellular cathepsins inhibits hepatitis E virus infection

M. Kloehn, T. Burkard, J. Janzen, J. A. Schrader, A. Goemer, R. J. P. Brown, V. L. Dao Thi, V. Kinast, Y. Brueggemann, D. Todt, E. Steinmann

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.

bioRxiv · Nov 3, 2023 · PreprintCell Biology

Comparable environmental stability and disinfection profiles of the currently circulating SARS-CoV-2 variants of concern B.1.1.7 and B.1.351

T. L. Meister, J. Fortmann, D. Todt, N. Heinen, A. Ludwig, Y. Brueggemann, C. Elsner, U. Dittmer, S. Pfaender, E. Steinmann

This study compares the environmental stability and disinfection profiles of SARS-CoV-2 variants B.1.1.7 and B.1.351 to the wildtype, finding comparable susceptibility to disinfection and surface stability.

bioRxiv · Apr 7, 2021Microbiology

A realistic touch-transfer method reveals low risk of transmission for SARS-CoV-2 by contaminated coins and bank notes

D. Todt, T. L. Meister, B. Tamele, J. Howes, D. Paulmann, B. Becker, F. H. Brill, M. Wind, J. Schijven, B. Mhlekude, C. Goffinet, A. Krawczyk, J. Steinmann, S. Pfaender, Y. Brueggemann, E. Steinmann

This study assesses the risk of SARS-CoV-2 transmission via contaminated coins and banknotes using a novel touch transfer method and shows it is unlikely under typical conditions.

bioRxiv · Apr 2, 2021Microbiology

A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets

A. Kratzel, J. N. Kelly, Y. Brueggemann, J. Portmann, P. V'kovski, D. Todt, N. Ebert, E. Steinmann, R. Dijkman, G. Zimmer, S. Pfaender, V. Thiel

This study identifies autophagy-related host factors as conserved targets for coronavirus replication using CRISPR screens and shows that immunophilin inhibitors can block viral replication.

bioRxiv · Feb 24, 2021Microbiology