The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

DOI 10.1038/s41467-023-40151-x

humanstructural biology

𝕏 PostBluesky

ImmunologybioRxivNov 10, 2021

A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

L. Jelinkova, Y. Flores-Garcia, S. Shapiro…·B. Chackerian

This study shows that a vaccine targeting the L9 epitope of CSP in Plasmodium falciparum provides protection against blood-stage malaria in mice.

DOI 10.1038/s41541-022-00457-1

mouseexperimental assay

𝕏 PostBluesky

ImmunologybioRxivAug 11, 2021

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

L. T. Wang, N. K. Hurlburt, A. Schon…·R. A. Seder

This study shows that the L9 antibody's light chain is essential for binding PfCSP minor repeats and enhancing neutralization of malaria sporozoites.

DOI 10.1016/j.celrep.2022.110367

humanplant (other)

𝕏 PostBluesky

MicrobiologybioRxivJul 18, 2020

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

T. Pholcharee, D. Oyen, Y. Flores-Garcia…·I. A. Wilson

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.

DOI 10.1038/s41467-021-21221-4

plant (other)protein structure

𝕏 PostBluesky