C. R. King

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex

This paper develops a combination malaria vaccine targeting the RCR-complex by fusing epitopes from RIPR to CyRPA, improving in vitro growth inhibition compared to RH5.1 alone.

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

Target-agnostic identification of human antibodies to Plasmodium falciparum sexual forms reveals cross stage recognition of glutamate-rich repeats

The paper identifies human antibodies targeting Plasmodium falciparum sexual stages, revealing cross-stage recognition of glutamate-rich repeats through a novel method.

Pathogen-driven CRISPR screens identify TREX1 as a regulator of DNA self-sensing during influenza virus infection

The paper uses a CRISPR screen to identify TREX1 as a pro-viral host factor that modulates DNA sensing during influenza infection.

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

Vacuole phase-partitioning boosts mitochondria activity and cell lifespan through an inter-organelle lipid pipeline

The paper identifies a lipid trafficking pathway between yeast vacuoles and mitochondria that enhances mitochondrial activity and cell lifespan under glucose starvation.

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.

Cryo-EM structure of the circumsporozoite protein of Plasmodium falciparum with a vaccine-elicited antibody reveals maturation of inter-antibody contacts

The paper presents a cryo-EM structure of Plasmodium falciparum CSP with vaccine-elicited antibodies, revealing a spiral conformation stabilized by inter-antibody contacts.