Matriptase generates a tissue damage response via promoting Gq signalling, leading to RSK and DUOX activation
J. Ma, C. A. Scott, Y. N. Ho, K. S. Marsay, C. Zhang, C. K. J. Teow, S. S. Ng, W. Zhang, V. Tergaonkar, L. J. Partridge, S. Roy, E. Amaya, T. J. Carney
This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.
bioRxiv · Jan 21, 2021 · PreprintCell Biology