Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice
Y. A. Chiao, H. Zhang, M. Sweetwyne, J. Whitson, Y. S. Ting, N. Basisty, L. Pino, E. Quarles, N.-H. Nguyen, M. Campbell, T. Zhang, M. J. Gaffrey, G. Merrihew, L. Wang, Y. Yue, , P. S. Rabinovitch
This study shows that treating old mice with SS-31 improves cardiac diastolic function by reducing mitochondrial oxidative stress and restoring redox balance.
bioRxiv · Jan 2, 2020Physiology