Y. Sei

Loss of PI3-kinase activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

This study shows that IPMK's PI3-kinase activity is essential for PDK1 membrane localization, which activates AKT and supports intestinal homeostasis and regeneration.

In vivo CRISPRi screen reveals the differential requirement for mitochondrial respiratory chain function between in vivo and in vitro tumor growth

The paper uses CRISPRi to show that mitochondrial respiratory chain genes are critical for in vivo tumor growth but not for metastasis in lung cancer xenografts.