Author

R. Okimoto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

T. Bivona· 2 shared W. Wu· 2 shared A. Urisman· 1 shared C. Blakely· 1 shared C. Luck· 1 shared D. Laurent· 1 shared D. Tan· 1 shared E. Small· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

T. Bivona

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4 papers

Recent·Most cited

Mapping chromatin state and transcriptional response in CIC-DUX4 undifferentiated round cell sarcoma

N. Thomas, C. Luck, N. Shlimon, R. Kriska Ponce, Z. Kosibaty, R. Okimoto

This study identifies CIC-DUX4-mediated chromatin states and transcriptional responses in sarcoma using ChIP and RNA-Seq analysis of patient-derived cells.

bioRxiv · Oct 11, 2023 · PreprintCancer Biology

The CIC-ERF co-deletion underlies fusion independent activation of ETS family member, ETV1, to drive prostate cancer progression

N. Gupta, H. Song, W. Wu, R. Ponce, Y. Lin, J. W. Kim, E. Small, F. Feng, F. W. Huang, R. Okimoto

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

bioRxiv · Jan 26, 2022Cancer Biology

In vivo CRISPRi screen reveals the differential requirement for mitochondrial respiratory chain function between in vivo and in vitro tumor growth

H. Nakaoka, N. Bennett, R. Okimoto, D. Laurent, Y. Sei, T. Bivona, J. ten Hoeve, T. Graeber, K. Nakamura, J. Nakamura

The paper uses CRISPRi to show that mitochondrial respiratory chain genes are critical for in vivo tumor growth but not for metastasis in lung cancer xenografts.

bioRxiv · Oct 3, 2021 · PreprintCancer Biology

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

S. Nanjo, W. Wu, N. Karachaliou, C. Blakely, J. Suzuki, S. Ali, L. Kerr, V. Olivas, J. Shue, J. Rotow, M. Mayekar, F. Haderk, N. Chatterjee, A. Urisman, Y. Kirichok, , T. Bivona

This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.

bioRxiv · Oct 26, 2020 · PreprintCancer Biology