Author

D. Laurent

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Barthelemy· 1 shared A. Bongiovanni· 1 shared A. Plesa· 1 shared C. Berthon· 1 shared C. PREUDHOMME· 1 shared C. ROUMIER· 1 shared E. Rose· 1 shared F. Gonzales· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Barthelemy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tetraspanin CD81 promotes leukemia stem cell function and represents a new therapeutic vulnerability in acute myeloid leukemia

F. Gonzales, P. Peyrouze, T. Boyer, S. Guihard, F. Sevrin, D. LAURENT, A. Plesa, A. Barthelemy, A. Bongiovanni, N. Pottier, C. PREUDHOMME, N. DUPLOYEZ, C. Berthon, C. ROUMIER, M. CHEOK

This study identifies CD81 as a marker of aggressive AML and shows anti-CD81 therapy improves survival in AML models.

bioRxiv · Sep 20, 2023 · PreprintCancer Biology

In vivo CRISPRi screen reveals the differential requirement for mitochondrial respiratory chain function between in vivo and in vitro tumor growth

H. Nakaoka, N. Bennett, R. Okimoto, D. Laurent, Y. Sei, T. Bivona, J. ten Hoeve, T. Graeber, K. Nakamura, J. Nakamura

The paper uses CRISPRi to show that mitochondrial respiratory chain genes are critical for in vivo tumor growth but not for metastasis in lung cancer xenografts.

bioRxiv · Oct 3, 2021 · PreprintCancer Biology

Absolute measurement of the tissue origins of cell-free DNA in the healthy state and following paracetamol overdose

D. Laurent, F. Semple, P. J. Starkey Lewis, E. Rose, H. A. Black, S. J. Forbes, M. J. Arends, J. W. Dear, T. J. Aitman

This study directly measures the tissue origins of cell-free DNA in healthy mice and after paracetamol overdose, showing increased liver contribution in cases of liver injury.

bioRxiv · Jul 26, 2019Pharmacology & Toxicology