Author

Y. Seif

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:drug response / drug discovery· 4 Organism:human· 4 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

S. Poudel· 6 shared R. Szubin· 5 shared V. Nizet· 5 shared A. Rajput· 4 shared B. Palsson· 4 shared C. Olson· 4 shared H. Tsunemoto· 4 shared J. Monk· 4 shared

Activity by Year

2020-2021 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMicrobiology

S. Poudel

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains

Y. Gao, S. Poudel, Y. Seif, Z. Shen, B. O. Palsson

This study identifies the CodY regulon in two closely related S. aureus USA300 strains, revealing conserved and strain-specific regulatory patterns and metabolic roles of CodY.

bioRxiv · Jan 8, 2021 · PreprintMicrobiology

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

S. Poudel, H. Tsunemoto, Y. Seif, A. V. Sastry, R. Szubin, S. Xu, H. Machado, C. Olson, A. Anand, J. Pogliano, V. Nizet, B. Palsson

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

Proceedings of the National Academy of Sciences · Jul 2, 2020Peer-reviewedMicrobiology

Environmental conditions dictate differential evolution of vancomycin resistance in Staphylococcus aureus

H. Machado, Y. Seif, G. Sakoulas, C. A. Olson, R. Szubin, B. Palsson, V. Nizet, A. M. Feist

This study identifies media-specific mutational mechanisms of vancomycin resistance in S. aureus using adaptive laboratory evolution and sequencing.

bioRxiv · Jun 7, 2020Microbiology

Characterizing the response of Acinetobacter baumannii ATCC 17978 to azithromycin in multiple in vitro growth conditions

N. A. Dillon, Y. Seif, H. Tsunemoto, S. Poudel, M. Meehan, R. Szubin, C. Olson, A. Rajput, G. Alarcon, A. Lamsa, A. Vrbanac, J. Sugie, S. Dahesh, J. Monk, P. Dorrestein, , V. Nizet

This study examines how MDR A. baumannii responds to azithromycin in different growth conditions using multiple analytical techniques.

bioRxiv · May 19, 2020 · PreprintMicrobiology

Identifying the effect of vancomycin on HA-MRSA strains using bacteriological and physiological media

A. Rajput, S. Poudel, H. Tsunemoto, M. Meehan, R. Szubin, C. Olson, Y. Seif, A. Lamsa, N. Dillon, A. Vrbanac, J. Sugie, S. Dahesh, J. Monk, P. Dorrestein, J. Pogliano, , B. O. Palsson

The paper examines vancomycin's effect on HA-MRSA USA100 strains using bacteriological and physiological media through growth curves, RNA sequencing, and exo-metabolomics.

bioRxiv · May 6, 2020 · PreprintMicrobiology

Profiling the effect of nafcillin on HA-MRSA D592 using bacteriological and physiological media

Y. Seif, S. Poudel, H. Tsunemoto, R. Szubin, M. J. Meehan, C. Olson, A. Rajput, G. Alarcon, A. Lamsa, N. Dillon, A. Vrbanac, J. Sugie, S. Daesh, J. Monk, P. Dorrestein, , V. Nizet

This study investigates how nafcillin affects HA-MRSA D592 in different media types, revealing media-dependent antibiotic activity through multi-dimensional analysis.

bioRxiv · Apr 30, 2020 · PreprintMicrobiology

Pangenome analytics reveal two-component systems as conserved targets in ESKAPEE pathogens

A. Rajput, Y. Seif, K. S. Choudhary, C. Dalldorf, S. Poudel, J. Monk, B. O. Palsson

This study uses pangenome analytics to analyze two-component systems in ESKAPEE pathogens, revealing their phylogenetic distribution and sequence variation, and highlights their potential as targets for antibiotic resistance.

bioRxiv · Apr 25, 2020Microbiology