Author

A. V. Sastry

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Bioengineering· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:gene regulatory network inference· 5 Approach:statistical model· 5 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 4 Organism:E. coli· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3

Frequent Co-Authors

B. O. Palsson· 6 shared R. Szubin· 6 shared S. Poudel· 4 shared V. Nizet· 4 shared Y. Gao· 4 shared Y. Hefner· 4 shared S. Xu· 3 shared B. Palsson· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersMicrobiology

B. O. Palsson

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Author profile →

8 papers

Recent·Most cited

Proteome allocation is linked to transcriptional regulation through a modularized transcriptome

A. Patel, D. McGrosso, Y. Hefner, A. Campeau, A. V. Sastry, S. Maurya, K. Rychel, D. J. Gonzalez, B. O. Palsson

The paper investigates modularization of bacterial transcriptomes and proteomes to uncover relationships between their compositions and regulatory mechanisms.

bioRxiv · Feb 20, 2023Bioengineering

Elucidation of independently modulated genes in Streptococcus pyogenes reveals carbon sources that control its expression of hemolytic toxins

Y. Hirose, S. Poudel, A. V. Sastry, R. Szubin, D. C. Zielinski, H. G. Lim, N. D. Menon, H. Bergsten, S. Uchiyama, T. Hanada, S. Kawabata, B. O. Palsson, V. Nizet

The paper identifies carbon sources that regulate hemolytic toxin expression in Streptococcus pyogenes using transcriptome-wide independent component analysis.

bioRxiv · Aug 4, 2022Microbiology

Coordination of CcpA and CodY regulators in Staphylococcus aureus USA300 strains

S. Poudel, Y. Hefner, R. Szubin, A. V. Sastry, Y. Gao, V. Nizet, B. O. Palsson

This paper uses ICA to modularize the TRN of S. aureus USA300 and combines it with a metabolic model to show coordination between CcpA and CodY in regulating carbon and amino acid metabolism.

bioRxiv · May 25, 2022Microbiology

Revealing 29 sets of independently modulated genes in Staphylococcus aureus, their regulators and role in key physiological responses

S. Poudel, H. Tsunemoto, Y. Seif, A. V. Sastry, R. Szubin, S. Xu, H. Machado, C. Olson, A. Anand, J. Pogliano, V. Nizet, B. Palsson

This paper identifies 29 independently modulated gene sets in S. aureus using ICA, linking them to regulators and physiological responses.

Proceedings of the National Academy of Sciences · Jul 2, 2020Peer-reviewedMicrobiology

Decomposition of transcriptional responses provides insights into differential antibiotic susceptibility

A. V. Sastry, N. Dillon, S. Poudel, Y. Hefner, S. Xu, R. Szubin, A. Feist, V. Nizet, B. Palsson

The paper investigates how media composition affects antibiotic susceptibility in E. coli using transcriptomics and machine learning, identifying key regulators and shifts in respiration and iron availability.

bioRxiv · May 4, 2020 · PreprintMicrobiology

PtrR (YneJ) is a novel E. coli transcription factor regulating the putrescine stress response and glutamate utilization

I. A. Rodionova, Y. Gao, A. V. Sastry, J. Monk, n. wong, R. Szubin, H. Lim, Z. Zhang, M. H. Saier, B. O. Palsson

This paper identifies PtrR as a dual activator/repressor in E. coli that regulates putrescine stress response and glutamate utilization through transcriptional control of multiple genes.

bioRxiv · Apr 27, 2020 · PreprintMicrobiology

Adaptive laboratory evolution of Escherichia coli under acid stress

B. Du, C. A. Olson, A. V. Sastry, X. Fang, P. V. Phaneuf, K. Chen, M. Wu, R. Szubin, S. Xu, Y. Gao, Y. Hefner, A. M. Feist, B. O. Palsson

This study evolves E. coli under acid stress and identifies genetic and expression changes that enhance acid tolerance.

bioRxiv · Jun 4, 2019Microbiology

Systematic discovery of uncharacterized transcription factors in Escherichia coli K-12 MG1655

Y. Gao, J. T. Yurkovich, S. W. Seo, I. Kabimoldayev, A. Drager, K. Chen, A. V. Sastry, X. Fang, N. Mih, L. Yang, J. Eichner, B.-K. Cho, D. Kim, B. O. Palsson

This study identifies and characterizes 16 uncharacterized transcription factors in E. coli K-12 MG1655 using computational prediction and experimental validation.

bioRxiv · Jun 11, 2018Microbiology