Author

Y. Takeshima

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

D. Motooka· 2 shared D. Okuzaki· 2 shared H. Mochizuki· 2 shared M. Arai· 2 shared M. Kinoshita· 2 shared N. Ohkura· 2 shared S. Sakaguchi· 2 shared T. Okuno· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

D. Motooka

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-cell transcriptome landscape of circulating CD4+ T cell populations in human autoimmune diseases

Y. Yasumizu, D. Takeuchi, R. Morimoto, Y. Takeshima, T. Okuno, M. Kinoshita, T. Morita, Y. Kato, M. Wang, D. Motooka, D. Okuzaki, Y. Nakamura, N. Mikami, M. Arai, X. Zhang, , S. Sakaguchi

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

bioRxiv · May 9, 2023Immunology

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Y. Yasumizu, N. Ohkura, H. Murata, M. Kinoshita, S. Funaki, S. Nojima, K. Kido, M. Kohara, D. Motooka, D. Okuzaki, S. Suganami, E. Takeuchi, Y. Nakamura, Y. Takeshima, M. Arai, , H. Mochizuki

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

bioRxiv · Dec 19, 2021Immunology

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

Y. Takeshima, Y. Iwasaki, M. Nakano, Y. Narushima, M. Ota, Y. Nagafuchi, S. Sumitomo, T. Okamura, K. B. Elkon, K. Ishigaki, A. Suzuki, Y. Kochi, K. Yamamoto, K. Fujio

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

bioRxiv · Oct 8, 2021 · PreprintImmunology