M. Kinoshita

Effect of Light and Water Agitation on Hatching Processes in Clown Anemonefish Amphiprion ocellaris

This study shows that darkness and water agitation regulate hatching enzyme secretion and chorion digestion in clown anemonefish, enabling synchronized hatching.

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

FliH and FliI help FlhA bring strict order to flagellar protein export in Salmonella

This study identifies the role of FlhA's GYXLI motif and the flagellar ATPase complex in regulating substrate specificity switching of the fT3SS during flagellar assembly in Salmonella.

mRNA vaccine induces protective immunity against the type III secretory virulence of Pseudomonas aeruginosa

This study develops an mRNA vaccine targeting Pseudomonas aeruginosa's type III secretion system, showing improved mouse survival and reduced lung bacterial load after challenge.

Single-cell transcriptome landscape of circulating CD4+ T cell populations in human autoimmune diseases

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

Conserved GYXLI motif of FlhA is involved in dynamic domain motions of FlhA required for flagellar protein export

This study identifies the conserved GYXLI motif in FlhA as critical for dynamic domain motions in FlhAC, enabling efficient flagellar protein export via the fT3SS.

Adenylate kinase 1 overexpression increases locomotor activity in medaka fish

This study shows that overexpressing adenylate kinase 1 in medaka fish increases locomotor activity, which is temperature-dependent.

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

This study identifies a unique adhesive motif in P5 that enables dimerization, which is essential for its structural stability and functional roles in ER quality control.

Native structure of flagellar MS ring is formed by 34 subunits with 23-fold and 11-fold subsymmetries

The paper determines the native structure of the bacterial flagellar MS ring, revealing it is 34-fold symmetric with 23-fold and 11-fold subsymmetries in its inner and middle regions.

The FlhA linker mediates flagellar protein export switching during flagellar assembly

The paper identifies FlhA's linker as a switch that regulates flagellar protein export specificity during assembly by interacting with FlhAC to control chaperone binding.

Membrane voltage-dependent activation of the flagellar protein export engine

The paper investigates how membrane voltage influences flagellar protein export by showing that a voltage increase recovers export in the absence of ion gradients.

The FlgN chaperone activates the Na+-driven engine of the flagellar protein export apparatus

The paper identifies FlgN as a chaperone that activates the Na+-driven export mechanism in the absence of the ATPase complex in bacterial flagellar protein export.

Expression of Ace2, Tmprss2, and Furin in mouse ear tissue

This study examines the expression of Ace2, Tmprss2, and Furin in mouse ear tissues, finding co-expression in the middle ear that suggests susceptibility to SARS-CoV-2.

Lipopolysaccharide preconditioning augments phagocytosis of malaria-parasitized red blood cells through induced bone marrow-derived macrophages in the liver, thereby increasing the murine survival after Plasmodium yoelii infection

This study shows that LPS preconditioning enhances phagocytic clearance of malaria parasites by liver macrophages, improving survival in mice infected with Plasmodium yoelii.

Production of a tributyltin-binding protein 2 knockout mutant strain of Japanese medaka, Oryzias latipes

This study generates a TBT-bp2 knockout medaka strain to investigate the function and detoxification mechanisms of tributyltin-binding proteins.

Epidemiological survey of serum titers from adults against various Gram-negative bacterial V-antigens

The paper measures serum titers against five Gram-negative bacterial V-antigens in adults and finds high cross-correlation between some antigens, suggesting potential for epidemiological studies.

Zinc Boosts EGCG’s hIAPP Amyloid Inhibition Both in Solution and Membrane

This study shows that zinc enhances EGCG's ability to inhibit hIAPP amyloid aggregation both in solution and in the presence of lipid membranes.

A lncRNA/Lin28/Let7 Axis Coupled To DNA Methylation Fine Tunes The Dynamics Of A Cell State Transition

The paper identifies a lncRNA/miRNA/DNA methylation axis that regulates the timing of stem cell state transition from naive pluripotency.