M. Arai

Inosine Triphosphate Pyrophosphatase as a Candidate Associated with White Matter Abnormalities in Chronic Heart Failure

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

Single-cell transcriptome landscape of circulating CD4+ T cell populations in human autoimmune diseases

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

Reentrant condensation of a multicomponent complex system of biomolecules induced by polyphosphate

The paper investigates reentrant condensation in a multicomponent biomolecular system using a cola/milk mixture and explains the mechanism through reduced pure-component systems.

Structure and Function of Gli123 Involved in Mycoplasma mobile Gliding

This study investigates the structure and function of Gli123, a surface protein essential for Mycoplasma mobile gliding, revealing its conformational changes and evolutionary implications.

Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy

This study uses hit-and-run silencing to suppress DUX4 in FSHD patient-derived iPSCs by targeting DNA hypomethylation on D4Z4 repeats, achieving sustained suppression for at least two weeks.

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

GUN1 regulates tetrapyrrole biosynthesis

This study identifies GUN1's role in chloroplast-to-nucleus retrograde signaling by showing it binds heme, affects tetrapyrrole biosynthesis, and enhances FC1 activity.

Spatial and temporal translocation of PKCα in single endothelial cell in response to focal mechanical stimulus

The paper investigates PKCα translocation in endothelial cells under mechanical stress, finding biphasic movement requiring Ca2+ and DAG for initial translocation and MS channels for secondary translocation.