Author

H. Mochizuki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

D. Motooka· 3 shared D. Okuzaki· 3 shared M. Kinoshita· 3 shared N. Ohkura· 3 shared T. Okuno· 3 shared Y. Yasumizu· 3 shared C. Aguirre· 2 shared E. MOrii· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

D. Motooka

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

Y. Yasumizu, M. Kinoshita, M. J. Zhang, D. Motooka, K. Suzuki, D. Okuzaki, S. Nojima, S. Funaki, Y. Shintani, N. Ohkura, E. MOrii, T. Okuno, H. Mochizuki

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

bioRxiv · Feb 5, 2024 · PreprintImmunology

Single-cell transcriptome landscape of circulating CD4+ T cell populations in human autoimmune diseases

Y. Yasumizu, D. Takeuchi, R. Morimoto, Y. Takeshima, T. Okuno, M. Kinoshita, T. Morita, Y. Kato, M. Wang, D. Motooka, D. Okuzaki, Y. Nakamura, N. Mikami, M. Arai, X. Zhang, , S. Sakaguchi

The paper identifies 12 transcriptional gene programs in CD4+ T cells from autoimmune diseases and shows their utility in disease characterization and prediction.

bioRxiv · May 9, 2023Immunology

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs

C. Aguirre, Y. Miyanoiri, M. So, H. Tamaki, T. Maruno, J. Doi, N. Wang, K. Yamaguchi, K. Nakajima, Y. Yamamori, H. Inoura, C.-J. Choong, K. Kakuda, T. Ajiki, Y. Kimura, , H. Mochizuki

This study identifies a conformational switch in the alpha-synuclein C-terminus domain that determines fibril polymorphs by altering morphology in response to ionic strength and temperature.

bioRxiv · Feb 10, 2022 · PreprintBiophysics

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis

K. Nakajima, K. Yamaguchi, M. Noji, C. Aguirre, K. Ikenaka, H. Mochizuki, L. Zhou, H. Ogi, T. Ito, I. Narita, F. Gejyo, H. Naiki, S. Yamamoto, Y. Goto

This study identifies serum albumin concentration as a tertiary risk factor for dialysis-related amyloidosis, showing that maintenance dialysis improves outcomes by increasing serum component concentrations.

bioRxiv · Feb 1, 2022Biophysics

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Y. Yasumizu, N. Ohkura, H. Murata, M. Kinoshita, S. Funaki, S. Nojima, K. Kido, M. Kohara, D. Motooka, D. Okuzaki, S. Suganami, E. Takeuchi, Y. Nakamura, Y. Takeshima, M. Arai, , H. Mochizuki

This study identifies neuromuscular gene expression in thymoma-associated myasthenia gravis by analyzing bulk and single-cell RNA-seq data, linking it to specific thymic epithelial cell subpopulations.

bioRxiv · Dec 19, 2021Immunology