Y. Xie

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

This study shows that sgRNA expression level is a major determinant of CRISPRi knockdown efficiency in K562 cells, more impactful than KRAB-dCas9 expression level.

This paper investigates carbon metabolism, transcriptome, and RNA editome changes during developmental path differentiation in Coprinopsis cinerea, revealing key metabolic pathways and evolutionary transcriptomic patterns.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

The paper shows glucocorticoids inhibit macrophage differentiation to a pro-inflammatory phenotype but not their migration in a zebrafish wound model.

The paper describes the discovery and characterization of a novel Klebsiella species, Klebsiella huaxiensis, isolated from a human urine sample.

This study uses a deep CNN to analyze lung cancer pathology images, identifies tumor shape features linked to survival, and develops a prognostic model validated in an independent cohort.

The paper develops and validates a nomogram prognostic model for small-cell lung cancer patients using clinical data from the National Cancer Database.

The paper constructs a lung cancer database with gene expression and clinical data from 6,700 patients and develops an open web portal for data exploration and analysis.

This study identifies the fibronectin type III and intracellular domains of Tril as essential for its function in Smad7 degradation and signaling during Xenopus embryogenesis.