Y. Xie

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.

The paper presents a cryo-EM structure of the yeast THO*Sub2 complex and shows its interaction with the SR-like protein Gbp2, suggesting a role in mRNP maturation.

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

This study develops engineered red blood cells expressing a PCSK9 inhibitor to lower LDL and prevent obesity in mice.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

The paper introduces a generative model to test hypotheses about cell-cell interactions in tumor microenvironments using synthetic multiplexed images.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This study shows that Mfge8 inhibits human gastric antrum smooth muscle contractions by reducing MYPT1 phosphorylation and LC20 phosphorylation through its interaction with 8β1 integrin.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

The paper investigates how multiple actin regulators coordinate to form complex 3D actin structures in vivo, identifying distinct roles and cooperative interactions among seven ANRPs.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

This study shows glucocorticoids reduce macrophage phagocytosis, increasing bacterial burden in a zebrafish tuberculosis model, which may explain increased susceptibility to tuberculosis in humans.

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

The paper shows that pericytes, not endothelial cells, express ACE2 in microvessels, suggesting they may be infected in COVID-19 and contribute to microvascular inflammation and hypercoagulopathy.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

This study uses OCT to monitor long-term tissue response around brain implants, finding that Parylene coatings do not reduce glial encapsulation.