Author

A.-C. Uhlemann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cell Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

D. A. Fidock· 2 shared S. Mok· 2 shared T. Yeo· 2 shared A. Chavez· 1 shared A. Chong· 1 shared A. H. Ricciuti· 1 shared A. Paudel· 1 shared A. Seddek· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

D. A. Fidock

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

K. Kumpornsin, T. Kochakarn, T. Yeo, M. Luth, R. D. Pearson, J. Hoshizaki, K. Schindler, S. Mok, H. Park, A.-C. Uhlemann, S. M. Cubel, V. Franco, M. Gomez-Lorenzo, F.-J. Gamo, E. Winzeler, , M. C. Lee

This study creates a mutator parasite of Plasmodium falciparum to enhance drug resistance discovery by increasing mutation rates and identifying resistance mechanisms.

bioRxiv · Aug 23, 2022 · PreprintMicrobiology

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

S. Iketani, H. Mohri, B. Culbertson, S. J. Hong, Y. Duan, M. I. Luck, M. K. Annavajhala, Y. Guo, Z. Sheng, A.-C. Uhlemann, S. P. Goff, Y. Sabo, H. Yang, A. Chavez, D. D. Ho

This study identifies multiple mutational pathways leading to nirmatrelvir resistance in SARS-CoV-2 through in vitro experiments and structural analysis.

bioRxiv · Aug 7, 2022Microbiology

Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses

N. Fukuma, M. L. Hulke, M. I. Brener, S. Golob, R. Zilinyi, Z. Zhou, C. Tzimas, I. Russo, C. McGroder, R. Pfeiffer, A. Chong, G. Zhang, D. Burkhoff, M. B. Leon, M. Maurer, , E. J. Tsai

This study identifies transcriptomic changes in cardiac fibroblasts associated with cardiac microthrombi in fatal COVID-19 through single nuclei RNA sequencing and clinical analyses.

bioRxiv · Jul 27, 2021Pathology

Alteration of menaquinone isoprenoid chain length and antibiotic sensitivity by single amino acid substitution in HepT

S. Panthee, A. Paudel, H. Hamamoto, A.-C. Uhlemann, K. Sekimizu

The paper identifies a single amino acid substitution in HepT that alters menaquinone chain length and increases antibiotic sensitivity in S. aureus Smith.

Frontiers in Microbiology · Aug 26, 2020Peer-reviewedMicrobiology

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

E. Yoo, C. J. Schulze, B. H. Stokes, O. Onguka, T. Yeo, S. Mok, N. F. Gnadig, Y. Zhou, K. Kurita, I. T. Foe, S. M. Terrell, M. J. Boucher, P. Cieplak, R. G. Linington, J. Z. Long, , M. Bogyo

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.

bioRxiv · Nov 1, 2019Cell Biology

Epidemiology of Staphylococcus aureus in Neonates on Admission to a Chinese Neonatal Intensive Care Unit

W. Geng, Y. Qi, W. Li, T. H. McConvillle, A. H. Ricciuti, E. Grohs, L. Saiman, A.-C. Uhlemann

The paper investigates S. aureus colonization and infection in Chinese NICU neonates, identifying common clones and risk factors for colonization.

bioRxiv · Jan 24, 2019Microbiology

Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

P. K. Garcia, T. Annamalai, W. Wang, R. S. Bell, D. Le, P. Martin Pancorbo, S. Sikandar, A. Seddek, X. Yu, D. Sun, A.-C. Uhlemann, P. B. Tiwari, F. Leng, Y.-C. Tse-Dinh

This study investigates the antimycobacterial mechanism of FP-11g, a fluoroquinophenoxazine compound, and identifies resistance mechanisms in Mycobacterium smegmatis.

bioRxiv · Nov 7, 2018Microbiology