The force-sensing GPCR LPHN2 is indispensable for normal auditory function
Z. Yang, M.-W. Wang, S.-H. Zhou, Z.-c. Song, K.-K. Zhu, X. Wen, Q.-Y. Zhang, Y. Guan, J.-R. Gao, X.-H. Wang, Y.-Q. Wang, W.-W. Liu, L. Xu, W. Xiong, R. Chai, , J.-P. Sun
This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.
bioRxiv · Oct 24, 2023 · PreprintPhysiology