Author

R. Chai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Animal Behavior & Cognition· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:electrophysiology· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

X. Yu· 3 shared Z. Yang· 3 shared F. Yi· 2 shared J. Sun· 2 shared M. Wang· 2 shared Q. Zhang· 2 shared S. Zhou· 2 shared W. Qin· 2 shared

Activity by Year

2021-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPhysiology

X. Yu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

M. Mason, O. Lapuente-Santana, A. S. Halkola, W. Wang, R. Mall, X. Xiao, J. Kaufman, J. Fu, J. Pfeil, J. Banerjee, V. Chung, H. Chang, S. D. Chasalow, H. Y. Lin, R. Chai, , B. G. Vincent

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Journal of Translational Medicine · Feb 21, 2024Peer-reviewedCancer Biology

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

Z. Yang, S. Zhou, Q. Zhang, Z. Song, W. Liu, Y. Sun, M. Wang, X. Fu, K. Zhu, Y. Guan, J. Qi, X. Wang, Y. Sun, Y. Lu, Y. Ping, , J. Sun

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

Force sensing GPR133 is essential for normal balance and modulates vestibular hair cell membrane excitability via Gi signaling and CNGA3 coupling

z. yang, s. zhou, m. wang, y. ping, x. fu, r. zhao, p. xiao, y. lu, q. zhang, z. song, y. xi, h. lin, y. zheng, w. qin, f. yi, , J. Sun

This study identifies GPR133 as a force-sensing GPCR essential for balance, showing it modulates vestibular hair cell excitability via Gi signaling and CNGA3 coupling.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

Z. Yang, M.-W. Wang, S.-H. Zhou, Z.-c. Song, K.-K. Zhu, X. Wen, Q.-Y. Zhang, Y. Guan, J.-R. Gao, X.-H. Wang, Y.-Q. Wang, W.-W. Liu, L. Xu, W. Xiong, R. Chai, , J.-P. Sun

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

A reverse-central-dogma pathway underlies ribosome-antibiotic efficacy and accelerates resistance evolution

Y. Zheng, R. Chai, Z. Xu, Y. He, P. Shen, J. Liu, T. Wang

This study reveals a reverse-central-dogma pathway by which ribosome antibiotics cause genomic instability and accelerate resistance evolution through transcription-translation coupling disruption.

bioRxiv · Aug 3, 2023 · PreprintMicrobiology

Fatigue Metabolites of Large Yellow Croaker and Construction of Swimming Model

R. Chai, H. Yin, R. Huo, X. Shui, H. Wang, L. Huang, P. Wang, Heng YinRunming Huo Xiaomei ShuiHanying WangLing HuangPing Wang

This paper assesses swimming fatigue in large yellow croakers by analyzing metabolites and constructs an endurance swimming model to inform aquaculture site selection.

bioRxiv · Dec 1, 2021 · PreprintAnimal Behavior & Cognition