The polyanionic drug suramin neutralizes histones and prevents endotheliopathy
N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman
This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.
bioRxiv · Dec 9, 2021Immunology