Author

Y. L. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:clinical cohort / trial· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. K. Sonkusare· 2 shared A. Elbadawi· 1 shared A. J. M. Wollman· 1 shared A. M. Sackheim· 1 shared A. Pietropaoli· 1 shared B. A. Bouchard· 1 shared B. Barrus· 1 shared B. E. Isakson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersImmunology

S. K. Sonkusare

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

RNA triplex structures revealed by WAXS-driven MD simulations

Y. L. Chen, W. He, S. Kirmizialtin, L. Pollack

This paper uses WAXS-driven MD simulations to reveal RNA triplex structures that are difficult to characterize by crystallography.

bioRxiv · Feb 13, 2022 · PreprintBiophysics

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

bioRxiv · Dec 9, 2021Immunology

Endothelial Pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure

Z. Daneva, M. Ottolini, Y. L. Chen, E. Klimentova, S. A. Shah, R. D. Minshall, C. I. Seye, V. E. Laubach, B. E. Isakson, S. K. Sonkusare

The paper shows endothelial Panx1-TRPV4 signaling via ATP and P2Y2R lowers pulmonary arterial pressure by reducing contractility.

bioRxiv · Mar 9, 2021Biochemistry

Categorical Assignment of Pulmonary Embolism is a Simple and More Accurate Indicator of Right Ventricular Dysfunction and Short Team Mortality

Y. L. Chen, C. Wright, A. Pietropaoli, A. Elbadawi, J. Delehanty, B. Barrus, I. Gosev, D. Trawick, D. Patel, S. Cameron

This study compares risk stratification methods for acute pulmonary embolism, finding that categorizing patients by right ventricular dysfunction is more accurate than existing scoring systems.

bioRxiv · May 20, 2019 · PreprintBiochemistry

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

M. Saldivia, S. P. S. Rao, E. Fang, E. Myburgh, E. Brown, A. J. M. Wollman, R. Ritchie, S. B. Lakhsminarayana, Y. L. Chen, D. Patra, H. X. Koh, S. Williams, F. Supek, D. Paape, C. Bower-Lepts, , J. C. Mottram

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

bioRxiv · Apr 24, 2019Microbiology