Author

M. T. Nelson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. M. Sackheim· 2 shared K. Freeman· 2 shared N. Villalba· 2 shared A. D. Bonev· 1 shared A. D'Alessandro· 1 shared B. A. Bouchard· 1 shared D. C. Hill-Eubanks· 1 shared D. Majumdar· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

A. M. Sackheim

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epidermal growth factor receptors in vascular endothelial cells contribute to functional hyperemia in the brain

H. R. Ferris, D. C. Hill-Eubanks, M. T. Nelson, G. C. Wellman, M. Koide

This study shows that endothelial EGFR signaling is crucial for functional hyperemia, as its deletion impairs cerebral blood flow responses to neuronal activity.

bioRxiv · Sep 15, 2023Physiology

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

bioRxiv · Dec 9, 2021Immunology

Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels

A. M. Sackheim, N. Villalba, M. Sancho, O. F. Harraz, A. D. Bonev, A. D'Alessandro, T. Nemkov, M. T. Nelson, K. Freeman

This study shows traumatic brain injury impairs vascular function by reducing Kir2.1 channel activity through PIP2 depletion caused by increased H2O2 and PLA2 activity.

bioRxiv · Jan 15, 2021Physiology

Interplay of the Trypanosome Lytic Factor and innate immune cells in the resolution of cutaneous Leishmania infection

J. Pant, M. Samanovic, M. T. Nelson, M. K. Keceli, J. Verdi, S. M. Beverley, J. Raper

This paper investigates how Trypanosome Lytic Factor (TLF) and neutrophils interact to reduce Leishmania major infection, showing TLF requires acidic phagosomes and surface glycoconjugates for parasite lysis.

bioRxiv · Jul 2, 2020Microbiology