Author

A. M. Sackheim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

K. Freeman· 2 shared M. T. Nelson· 2 shared N. Villalba· 2 shared A. D. Bonev· 1 shared A. D'Alessandro· 1 shared B. A. Bouchard· 1 shared D. Majumdar· 1 shared J. E. Boyson· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersImmunology

K. Freeman

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Author profile →

2 papers

Recent·Most cited

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

bioRxiv · Dec 9, 2021Immunology

Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels

A. M. Sackheim, N. Villalba, M. Sancho, O. F. Harraz, A. D. Bonev, A. D'Alessandro, T. Nemkov, M. T. Nelson, K. Freeman

This study shows traumatic brain injury impairs vascular function by reducing Kir2.1 channel activity through PIP2 depletion caused by increased H2O2 and PLA2 activity.

bioRxiv · Jan 15, 2021Physiology