The ubiquitin E3 ligase Huwe1 facilitates viral and self RNA sensing by RIG-I-like receptors
Timo Oosenbrug, Dennis Gravekamp, Adán Pinto-Fernández, Stefania Crotta, Katja Finsterbusch, Sander B. van der Kooij, Laurens R. ter Haar, Yanniek Asschert, Gilaine F.E. Kleian, Benedikt Mathias Kessler, Andreas Wack, Annemarthe G. van der Veen
This study shows Huwe1 is essential for RIG-I-like receptor-mediated type I and III IFN induction by ubiquitinating key pathway components like TRAF5.
bioRxiv · Mar 27, 2025 · PreprintImmunology