Author

John E. Phay

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteORCID 0000-0002-8482-2137Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Barbra S. MilleriD· 2 shared Daniel M. ChopykiD· 2 shared Liudmila V. PopovaiD· 2 shared Priya H. DedhiaiD· 2 shared Adithe RivaldiiD· 1 shared Barbara BedogniiD· 1 shared Caleb Araujo· 1 shared Changxian SheniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Barbra S. MillerORCID

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2 papers

Recent·Most cited

Targeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma

Changxian Shen, Liudmila V. Popova, Daniel M. Chopyk, Lindsey Hartshorn, Zhongguang Li, Yaoling Shu, Caleb Araujo, Shivam Priya, Varsha Thakur, John E. Phay, Barbra S. Miller, Barbara Bedogni, Haichang Li, Priya H. Dedhia

This study shows MMP-14 is critical for ACC cell survival and DNA repair, and its inhibition reduces viability and impairs repair mechanisms.

bioRxiv · Jan 7, 2026 · PreprintCancer Biology

Single Nuclei Sequencing Reveals Replication Stress in Adrenocortical Carcinoma

Liudmila V. Popova, Elizabeth A. R. Garfinkle, Daniel M. Chopyk, Jaye B. Navarro, Adithe Rivaldi, Yaoling Shu, Elena E. Lomonosova, John E. Phay, Barbra S. Miller, Swati Sattuwar, Mary M. Mullen, Elaine R. Mardis, Katherine E. Miller, Priya H. Dedhia

The paper uses single nuclei RNA sequencing to identify replication stress and DNA damage response in adrenocortical carcinoma, suggesting ATR as a potential therapeutic target.

bioRxiv · Sep 30, 2024 · PreprintCancer Biology