Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm lineage diversification during foregut organogenesis
Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra K. Eicher, Lauren E. Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn
The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.
Nature Communications · Aug 27, 2020Peer-reviewedDevelopmental Biology