Author

Hiroyuki Koike

Cincinnati Children's Hospital Medical CenterORCID 0000-0001-9934-6930Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hiroyuki Koike2 papers · Icahn School of Medicine at Mount Sinai

Biology Disciplines

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Developmental Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Aaron M. ZorniD· 2 shared James M. WellsiD· 2 shared Keishi KishimotoiD· 2 shared Kentaro IwasawaiD· 2 shared Mitsuru MorimotoiD· 2 shared Takanori TakebeiD· 2 shared Alexander J. BondociD· 1 shared Alexandra K. EicheriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersDevelopmental Biology

Aaron M. ZornORCID

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2 papers

Recent·Most cited

Primitive Hepatoblasts Driving Early Liver Development

Kentaro Iwasawa, Hiroyuki Koike, Hasan Al Reza, Yuka Milton, Keishi Kishimoto, Konrad Thorner, Marissa Granitto, Norikazu Saiki, Connie Santangelo, Kathryn Glaser, Masaki Kimura, Alexander J. Bondoc, Hee-Wong Lim, Mitsuru Morimoto, Makiko Iwafuchi, , Takanori Takebe

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

bioRxiv · Jun 8, 2025 · PreprintDevelopmental Biology

Single cell transcriptomics reveals a signaling roadmap coordinating endoderm and mesoderm lineage diversification during foregut organogenesis

Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C. Witcher, Alexandra K. Eicher, Lauren E. Haines, Yarim Lee, John M. Shannon, Mitsuru Morimoto, James M. Wells, Takanori Takebe, Aaron M. Zorn

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.

Nature Communications · Aug 27, 2020Peer-reviewedDevelopmental Biology