Keishi Kishimoto

The paper uses vessel organoids to study how different FOXF1 variants affect mesoderm and capillary development in humans, showing variant-specific disruptions and potential therapeutic rescue.

The paper identifies and characterizes a new population of early hepatoblasts in mouse and human liver development, showing their role in liver bud formation and their decline in later stages.

This study develops a human pluripotent stem cell-derived organoid system to investigate vascular, mesenchymal, and epithelial co-development in lung and intestinal organoids, revealing organ-specific endothelial and mesenchymal features.

The paper develops a method to engineer functional human gastrointestinal organoids by assembling cells from the three primary germ layers, revealing the role of the enteric nervous system in tissue development.

The paper uses single-cell transcriptomics to map endoderm-mesoderm interactions during foregut organogenesis and validates signaling pathways in mice, then generates mesoderm subtypes from human pluripotent stem cells.

This study identifies bidirectional Wnt signaling between endoderm and mesoderm as critical for tracheal identity in mouse and human, with implications for tissue repair.

The paper investigates the mechanisms regulating trachea and esophagus development in mice, showing that radial cell polarization and cartilage development control tube elongation and diameter.

This study identifies KCNJ13 as critical for tracheal tubulogenesis by maintaining ion homeostasis and actin polymerization in smooth muscle cells.