Jiong Shi

This study identifies a hybrid Gag lattice as an intermediate in HIV-1 maturation, showing it is stabilized by IP6 and essential for infectivity.

This study shows that cyclophilin A inhibits HIV-1 nuclear entry in mutants by reducing capsid elasticity, which is reversed by suppressor mutations.

This study uses cryo-correlative techniques to analyze HIV-1 nuclear import, revealing dependencies on capsid elasticity, nuclear pore adaptability, and CPSF6 binding.

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.