Author

Conall Mc Guinness

University of WollongongORCID 0000-0002-9733-6699Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Adeline Pichard-KostuchiD· 1 shared AidanDarian W Douglas· 1 shared Akshay DeshpandeiD· 1 shared Andrew D. GriffithsiD· 1 shared Antoine M. van OijeniD· 1 shared Ashwanth Christopher FrancisiD· 1 shared Christopher AikeniD· 1 shared Ghada H. MansouriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Adeline Pichard-KostuchORCID

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2 papers

Recent·Most cited

The host protein cyclophilin A inhibits HIV-1 nuclear entry by decreasing capsid elasticity

Jun Hong, Akshay Deshpande, Yatish Thakare, Lora Simonovsky, AidanDarian W Douglas, Conall Mc Guinness, Noa Rotem‐Dai, Michelle Kortyna, J. Ole Klarhof, Jiong Shi, Till Böcking, Leo C. James, Ashwanth Christopher Francis, Itay Y. Rousso, Christopher Aiken

This study shows that cyclophilin A inhibits HIV-1 nuclear entry in mutants by reducing capsid elasticity, which is reversed by suppressor mutations.

bioRxiv · Sep 3, 2025 · PreprintMicrobiology

Optimised Nanobody-based Quenchbodies for Enhanced Protein Detection

Jordan H. Cater, Nehad S. El Salamouni, Ghada H. Mansour, Sebastian Hutchinson, Conall Mc Guinness, Stefan H. Mueller, Richard R. Spinks, Nirukshan Shanmugam, Adeline Pichard-Kostuch, Viktor Zahoransky, Harshad B. Ghodke, Marco Ribezzi‐Crivellari, Haibo B. Yu, Antoine M. van Oijen, Andrew D. Griffiths, Lisanne M. Spenkelink

This study optimizes nanobody-based quenchbodies for enhanced protein detection, achieving fluorescence increases of 1.5-2.4-fold and detecting IL-6 down to 2 nM.

Communications Biology · Jun 18, 2025Peer-reviewedBioengineering