Alphaviral nonstructural protein-host RBP co-condensation as a mechanism to sustain virus replication
Yi Liu, Zhiying Yao, Yun Zhang, Zhenshuo Zhu, Ziqiu Wang, Qi Chen, Zemin Yang, Yexuan He, Xiaoxin Chen, Le Tian, Jiang Du, Jinjun Wu, Hong Joo Kim, Jing Huang, Yongdeng Zhang, , Peiguo Yang
This study identifies nsP3-RBP co-condensation as a mechanism alphaviruses use to sustain replication, showing disruption of these condensates can inhibit viral replication.
Molecular Cell · May 21, 2026Peer-reviewedCell Biology