Lamin A/C safeguards replication initiation by orchestrating chromatin accessibility and PCNA recruitment
Mengling Zhang, Wenxue Zhao, Zhiguang Xiao, Lei Chang, Xing Wang, Yichen Bai, Xiaodong Guan, Tianyan Liu, Zhaoru Zhang, Yan Li, Qing Li, Cheng Li, Dongyi Xu, Qian Peter Su, Yujie Sun
This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.
Cell Reports · Mar 1, 2026Peer-reviewedBiophysics