Stealth liposomes encapsulating a potent ACAT1/SOAT1 inhibitor F12511: pharmacokinetic, biodistribution and toxicity studies in wild-type mice, and efficacy studies in triple transgenic Alzheimer Disease mice.
Adrianna L. De La Torre, Thao Nguyen Thanh Huynh, Catherine C.Y. Chang, Darcy B. Pooler, Dylan B. Ness, Lionel D. Lewis, Sanjana Pannem, Yichen Feng, Kimberley S. Samkoe, William F. Hickey, Ta‐Yuan Chang
This study evaluates a nanoparticle-formulated ACAT1 inhibitor in mice, showing brain delivery and reduced AD pathology without toxicity.
bioRxiv · May 2, 2023 · PreprintNeuroscience