Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7
Jacob K. Hilton, Yifei Lin, Eric Sefah, Justin C. Deme, Joanne L. Parker, Matthew J. Langton, Michael Grabe, Susan M. Lea, Simon L. Newstead, Joseph A. Mindell
The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.
bioRxiv · Oct 1, 2025 · PreprintBiochemistry