Joanne L. Parker

The paper identifies PQLC2 as a lysosomal pH regulator that affects tau homeostasis through a CRISPRi screen in iPSC-derived neurons.

The paper determines the structure of cornichon receptors bound to an SLC transporter and shows how they couple membrane adaptation with cargo selection during ER export.

The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.

This study identifies DtpT as the primary dipeptide transporter in Staphylococcus aureus and reveals its role in glutathione uptake, enhancing bacterial survival in macrophages.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

This study uses molecular dynamics simulations to elucidate the conformational mechanism and proton-substrate coupling in mammalian POTs, revealing key structural differences and functional insights.