Author

Joseph A. Mindell

National Institutes of HealthORCID 0000-0002-6952-8247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Eric SefahiD· 1 shared Jacob K. HiltoniD· 1 shared Joanne L. ParkeriD· 1 shared Justin C. DemeiD· 1 shared Matthew J. LangtoniD· 1 shared Michael GrabeiD· 1 shared Simon L. NewsteadiD· 1 shared Susan M. LeaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Eric SefahORCID

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1 paper

Recent·Most cited

Mechanism of phosphoinositide regulation of lysosomal pH via inhibition of CLC-7

Jacob K. Hilton, Yifei Lin, Eric Sefah, Justin C. Deme, Joanne L. Parker, Matthew J. Langton, Michael Grabe, Susan M. Lea, Simon L. Newstead, Joseph A. Mindell

The paper investigates how PI(3,5)P2 regulates lysosomal pH by inhibiting ClC-7, showing structural changes in ClC-7 upon PI(3,5)P2 binding and linking this to disease mutations.

bioRxiv · Oct 1, 2025 · PreprintBiochemistry