Stromal Gasdermin D-mediated Pyroptosis Drives Maladaptive CD4⁺ T-cell Remodeling in Tet2-Deficient Hematopoiesis
Kehan Ren, Xu Han, Ermin Li, Pan Wang, Honghao Bi, Wenjie Cai, Inci Aydemir, Ching Man Wai, Hongshen Niu, Jing Yang, Yijie Liu, Brian Vadasz, Madina Jh. SUKHANOVA, Deyu Fang, Weiguo Cui, Peng Ji
This study shows that stromal gasdermin D-mediated pyroptosis promotes CD4⁺ T-cell remodeling in Tet2-deficient hematopoiesis by creating a feedback loop between stromal cells and immune cells.
bioRxiv · May 5, 2026 · PreprintCancer Biology