Kehan Ren

Binary-SPA: A Reference-Free Method for Cell Annotation in High-Resolution Spatial Transcriptomics

Binary-SPA improves cell type annotation in spatial transcriptomics by using a two-stage approach without requiring external reference data.

Stromal Gasdermin D-mediated Pyroptosis Drives Maladaptive CD4⁺ T-cell Remodeling in Tet2-Deficient Hematopoiesis

This study shows that stromal gasdermin D-mediated pyroptosis promotes CD4⁺ T-cell remodeling in Tet2-deficient hematopoiesis by creating a feedback loop between stromal cells and immune cells.

A 3D in vitro assay to study combined immune cell infiltration and cytotoxicity

This paper introduces a 3D in vitro assay to study immune cell infiltration and cytotoxicity in solid tumors, showing it captures key steps of immune cell interaction with the tumor microenvironment.

3D map-guided modeling of functional endometrial tissue using multi-compartment assembloids

This paper develops a 3D multi-compartment assembloid that mimics human endometrial tissue and its menstrual cycle phases, enabling study of compartment-specific hormonal responses and paracrine signaling.

DDX41 dissolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death