Deyu Fang

This paper introduces gANCHOR, a T-cell foundation model that predicts CAR T-cell immunotherapy response by integrating gene-level structure with clinical outcomes, achieving high F1 score and biological insights.

The paper develops an AI framework to analyze blood scans and predict patient outcomes by characterizing tumor-immune ecosystems in circulation.

This study shows that stromal gasdermin D-mediated pyroptosis promotes CD4⁺ T-cell remodeling in Tet2-deficient hematopoiesis by creating a feedback loop between stromal cells and immune cells.

This paper introduces an antibody language model (AbLM) to accelerate IgG screening and design for broad-spectrum antiviral therapy, achieving higher precision in predicting variant-resistant antibodies.

This study shows efineptakin alfa (NT-I7) improves survival and induces tertiary lymphoid structures in murine lung tumors, potentially enhancing immunotherapy efficacy.

The paper identifies a rare subset of CD4 and CD8 double positive T cells that form clusters with circulating tumor cells, promoting cancer metastasis through immune suppression and integrin-mediated interactions.

This study introduces a platform to map reactive cysteines on MHC-I-bound peptides and shows interferon-gamma increases reactivity at position 8 of 9-mer antigens.

This study investigates the role of the UPR in FXR null mice, finding that hepatic XBP1 activation provides protection against liver injury and tumor development.