Author

Yinhan Zhou

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 2 Research Focus:benchmarking· 1 Assay:proteomics· 1

Frequent Co-Authors

Allisa J. Clemens· 2 shared Claire B. DiscenzaiD· 2 shared Connie HaiD· 2 shared David TatarakisiD· 2 shared Elysia Roche· 2 shared Jason C. DugasiD· 2 shared Johann ChowiD· 2 shared Joseph W. LewcockiD· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Allisa J. Clemens

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2 papers

Recent·Most cited

Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution compared to standard antibodies

Nathalie Khoury, Michelle E. Pizzo, Claire B. Discenza, David A. Joy, David Tatarakis, Mihail Ivilinov Todorov, Moritz Negwer, Connie Ha, Gabrielly Lunkes de Melo, Lily Sarrafha, Matthew J. Simon, Darren Chan, Roni Chau, Kylie S. Chew, Johann Chow, , Y. Joy Yu Zuchero

This study compares the biodistribution of Fc-engineered molecules targeting BBB receptors with standard antibodies, showing distinct CNS and peripheral organ targeting.

bioRxiv · Jul 11, 2024 · PreprintNeuroscience

Targeting Transferrin Receptor to Transport Antisense Oligonucleotides Across the Blood-Brain Barrier

Scarlett J. Barker, Mai B. Thayer, Chaeyoung Kim, David Tatarakis, Matthew J. Simon, Rebekah L. Dial, Lizanne Nilewski, Robert C. Wells, Yinhan Zhou, Megan E. Afetian, Alfred E. Chappell, Kylie S. Chew, Johann Chow, Allisa J. Clemens, Claire B. Discenza, , Sarah L. DeVos

This paper demonstrates that systemically delivered OTV, a TfR-binding molecule, effectively transports ASO across the BBB, achieving widespread and sustained knockdown of target genes in the CNS of mice and non-human primates.

bioRxiv · Apr 25, 2023 · PreprintNeuroscience